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Clinical and Diagnostic Laboratory Immunology, 01 1995, 120-121, Vol 2, No. 1
Copyright © 1995 by the American Society for Microbiology. All rights reserved.

Time to peak serum antibody response to influenza vaccine

S Rastogi, PA Gross, J Bonelli, S Dran, RA Levandowski, C Russo, ME Weksler, D Kaye, M Levison and E Abrutyn
Department of Internal Medicine, Hackensack Medical Center, New Jersey 07601.

The time to the appearance of a peak serum antibody response to influenza virus vaccine is not clearly defined. We compared the most commonly used time intervals described in the literature--4 and 6 weeks after vaccination. We studied 118 elderly patients from three different geographic sites. The 1992 to 1993 trivalent inactivated influenza virus vaccine containing influenza virus A/Beijing/353/89 (H3N2), influenza virus A/Texas/36/91 (H1N1), and influenza virus B/Panama/45/90 was used. No statistically significant differences were found at the 4- and 6-week intervals after vaccination.