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Clinical and Vaccine Immunology, February 2008, p. 392-393, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00383-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Cryptococcal Glucoxylomannan Does Not Exhibit Cross-Reactivity in the MVista Histoplasma Antigen Enzyme Immunoassay{triangledown}

David Zhuang,1 Chadi Hage,2 Magdia De Jesus,3 Emily Hackett,1 Michelle Durkin,1 Thomas E. Davis,4 Arturo Casadevall,3 and L. Joseph Wheat1*

MiraVista Diagnostics, Indianapolis, Indiana 46241,1 Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans' Administration Hospital, Indianapolis, Indiana 46202,2 Albert Einstein College of Medicine, Bronx, New York 10461,3 Indiana University School of Medicine, Department of Pathology, Wishard Memorial Hospital, Indianapolis, Indiana 462024

Received 24 September 2007/ Returned for modification 10 November 2007/ Accepted 29 November 2007

The potential for cross-reaction between Cryptococcus neoformans and Histoplasma capsulatum in antigen assays was evaluated. We tested patient samples, spleens from infected mice, and purified polysaccharides in the MVista Histoplasma antigen enzyme immunoassay and cryptococcal antigen latex agglutination system for cross-reactivity, and none was observed.

* Corresponding author. Mailing address: MiraVista Diagnostics, 4444 Decatur Blvd., Suite 300, Indianapolis, IN 46241. Phone: (317) 856-2681. Fax: (317) 856-3685. E-mail: jwheat{at}miravistalabs.com

{triangledown} Published ahead of print on 12 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 392-393, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00383-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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