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Clinical and Vaccine Immunology, February 2008, p. 388-391, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00265-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Evaluation of the Ultrasensitive Human Immunodeficiency Virus Type 1 (HIV-1) p24 Antigen Assay Performed on Dried Blood Spots for Diagnosis of HIV-1 Infection in Infants{triangledown}

Janet C. Patton,1 Ashraf H. Coovadia,1 Tammy M. Meyers,1,3 and Gayle G. Sherman1,2,4*

Wits Pediatric HIV Clinics, Wits Health Consortium,1 Departments of Molecular Medicine and Hematology,2 Pediatrics, University of the Witwatersrand,3 National Health Laboratory Service, Johannesburg, South Africa4

Received 2 July 2007/ Returned for modification 9 September 2007/ Accepted 23 November 2007

The diagnostic accuracy of the modified p24 antigen assay performed on pediatric dried blood spots was evaluated. Samples analyzed within 6 weeks of collection yielded no false-positive results (specificity, 100%) and few false-negative results (sensitivity, 96.5% to 98.3%). Laboratory services with limited resources should assess this option for routine infant diagnosis.

* Corresponding author. Mailing address: P.O. Box 79722, Senderwood, 2145 Johannesburg, South Africa. Phone: 27-11-488 3693. Fax: 27-11-489 8589. E-mail: gayle.sherman{at}nhls.ac.za

{triangledown} Published ahead of print on 5 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 388-391, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00265-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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