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Clinical and Vaccine Immunology, February 2008, p. 385-387, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00414-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Performance Characteristics of Microparticle Enzyme and Chemiluminescence Immunoassays for Measurement of Anti-HBc Immunoglobulin M in Sera of Patients with HBeAg-Negative Chronic Hepatitis B Virus Infection{triangledown}

Emilia Hadziyannis,* Emanuel Manesis, Dimitrios Vassilopoulos, Anastasia Georgiou, and Athanasios Archimandritis

Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas. Sophias Ave., Athens 11527, Greece

Received 15 October 2007/ Returned for modification 29 October 2007/ Accepted 28 November 2007

The IMx, AxSym, and Architect immunoglobulin M anti-HBc assay systems for detecting hepatitis B virus e antigen-negative chronic hepatitis B virus infection were compared. Despite good intra- and interassay coefficients of variation, significantly different values and low correlation (overestimation by AxSym and underestimation by Architect) were observed. Association and cutoff values for distinguishing patients with viral replication should be established for all methods.

* Corresponding author. Mailing address: Academic Department of Medicine, Athens University School of Medicine, Hippokration General Hospital, 114 Vas. Sophias Ave., Athens 11527, Greece. Phone: 302107718645. Fax: 302107481771. E-mail: emhadzi{at}med.uoa.gr

{triangledown} Published ahead of print on 12 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 385-387, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00414-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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