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Clinical and Vaccine Immunology, February 2008, p. 379-381, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Modulation of Type 1 Diabetes Susceptibility by Tumor Necrosis Factor Alpha –308 G/A and Lymphotoxin Alpha +249 A/G Haplotypes and Lack of Linkage Disequilibrium with Predisposing DQB1-DRB1 Haplotypes in Bahraini Patients{triangledown}

Mouna Stayoussef,1 Fayza A. Al-Jenaidi,2,3 Abduljabbar Al-Abbasi,2,3 Khadija Al-Ola,3 Haya Khayyat,4 Touhami Mahjoub,1 and Wassim Y. Almawi2*

University of Monastir, Monastir, Tunisia,1 College of Medicine and Medical Sciences, Arabian Gulf University,2 Department of Pediatrics, Salmaniya Medical Complex, Manama, Bahrain,3 Bahrain Defense Forces Hospital, Rifaa, Bahrain4

Received 9 October 2007/ Accepted 25 October 2007

Tumor necrosis factor alpha (TNF-{alpha}) –308 G/A and lymphotoxin alpha (LT{alpha}) +249 A/G single-nucleotide polymorphisms were investigated in 228 type 1 diabetes mellitus (T1DM) patients and 240 controls. Only LT{alpha} +249G allele and +249G/+249G genotype frequencies were higher among patients, and no linkage disequilibrium was found between TNF-{alpha}/LT{alpha} alleles and susceptible/protective DRB1-DQB1 haplotypes. TNF-{alpha}/LT{alpha} T1DM-susceptible (–308G/+249G) and protective (–308G/+249A) haplotypes were identified.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wyalmawi{at}yahoo.co.uk

{triangledown} Published ahead of print on 7 November 2007.

Clinical and Vaccine Immunology, February 2008, p. 379-381, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00410-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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