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Clinical and Vaccine Immunology, February 2008, p. 320-326, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00381-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.

Humoral Immune Responses of Type 1 Diabetes Patients to Mycobacterium avium subsp. paratuberculosis Lend Support to the Infectious Trigger Hypothesis{triangledown}

Leonardo A. Sechi,1* Valentina Rosu,1 Adolfo Pacifico,1 Giovanni Fadda,2 Niyaz Ahmed,3 and Stefania Zanetti1

Dipartimento di Scienze Biomediche, Università di Sassari, Viale San Pietro 43b, 07100 Sassari, Italy,1 Istituto di Microbiologia, Università Cattolica del Sacro Cuore, Roma, Italy,2 Pathogen Evolution Laboratory, Centre for DNA Fingerprinting and Diagnostics, Hyderabad, India3

Received 14 September 2007/ Returned for modification 13 November 2007/ Accepted 29 November 2007

Mycobacterium avium subsp. paratuberculosis is a zoonotic pathogen whose association with Crohn's disease in humans is under scrutiny. The objective of this work was to investigate its association with other chronic diseases such as type 1 diabetes mellitus (T1DM), where the involvement of a persistent pathogen such as M. avium subsp. paratuberculosis could be the trigger. For this purpose, 59 diabetic patients and 59 healthy controls were investigated for the presence of antibodies against two recombinant proteins of M. avium subsp. paratuberculosis and the whole-cell lysate. Extremely significant humoral immune responses to recombinant heparin binding hemagglutinin and glycosyl transferase proteins and the whole-cell lysates of M. avium subsp. paratuberculosis bacilli were observed in T1DM patients and compared to those of healthy controls. Finding evidence of M. avium subsp. paratuberculosis involvement in T1DM is perhaps a novel finding that might serve as a foundation stone in establishing an infectious etiology for T1DM.

* Corresponding author. Mailing address: Dipartimento di Scienze Biomediche, Sezione di Microbiologia Clinica e Sperimentale, Viale San Pietro 43b, 07100 Sassari, Italy. Phone: 39079228303. Fax: 39079212345. E-mail: sechila{at}uniss.it

{triangledown} Published ahead of print on 12 December 2007.

Clinical and Vaccine Immunology, February 2008, p. 320-326, Vol. 15, No. 2
1071-412X/08/$08.00+0     doi:10.1128/CVI.00381-07
Copyright © 2008, American Society for Microbiology. All Rights Reserved.





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