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Clinical and Vaccine Immunology, July 2007, p. 926-928, Vol. 14, No. 7
1071-412X/07/$08.00+0     doi:10.1128/CVI.00450-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Needle-Free Skin Patch Delivery of a Vaccine for a Potentially Pandemic Influenza Virus Provides Protection against Lethal Challenge in Mice

Sanjay Garg,^1, Mary Hoelscher,^1, Jessica A. Belser,¹ Chong Wang,¹ Lakshmi Jayashankar,¹ Zhu Guo,¹ Ross H. Durland,² Jacqueline M. Katz,¹ and Suryaprakash Sambhara^1*

Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia 30333,¹ Altea Therapeutics, Tucker, Georgia 30084²

Received 20 November 2006/ Returned for modification 9 March 2007/ Accepted 30 April 2007

In the event of another influenza virus pandemic, strategies for effective mass vaccination will urgently be needed. We used a novel transdermal patch delivery technology, known as the PassPort system, to vaccinate mice with recombinant H5 hemagglutinin with or without immunomodulators. This needle-free form of vaccine delivery induced robust serum antibody responses that were augmented by different immunomodulators that stimulated the innate immune system and protected mice against lethal challenge with a highly pathogenic avian H5N1 influenza virus.

Published ahead of print on 9 May 2007.

S.G. and M.H. contributed equally to the present study.