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Clinical and Vaccine Immunology, June 2007, p. 792-795, Vol. 14, No. 6
1071-412X/07/$08.00+0     doi:10.1128/CVI.00478-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Noninferiority of Antibody Response to Human Papillomavirus Type 16 in Subjects Vaccinated with Monovalent and Quadrivalent L1 Virus-Like Particle Vaccines

Suzanne M. Garland,¹ Marc Steben,^2* Mauricio Hernandez-Avila,³ Laura A. Koutsky,⁴ Cosette M. Wheeler,⁵ Gonzalo Perez,⁶ Diane M. Harper,⁷ Sepp Leodolter,⁸ Grace W. K. Tang,⁹ Daron G. Ferris,¹⁰ Mark T. Esser,¹¹ Scott C. Vuocolo,¹¹ Micki Nelson,¹¹ Radha Railkar,¹¹ Carlos Sattler,¹¹ Eliav Barr,^11, on behalf of the 012 Study Investigators

Microbiology and Infectious Diseases Department, Royal Women's Hospital, Carlton, and Department of Obstetrics and Gynaecology, University of Melbourne, Melbourne, Victoria, Australia,¹ Direction Risques Biologiques, Environnementaux et Occupationnels, Institut National de Santé Publique du Québec, Montréal, Québec, Canada,² National Institute of Public Health, Cuernavaca, Morelos, Mexico,³ Department of Epidemiology, University of Washington, Seattle, Washington,⁴ Departments of Molecular Genetics and Microbiology and of Obstetrics and Gynecology, University of New Mexico, Albuquerque, New Mexico,⁵ National Research Center, Group Saludcoop, Bogotá, Colombia,⁶ Norris Cotton Cancer Center and Departments of Obstetrics and Gynecology and of Community and Family Medicine, Dartmouth Medical School, Hanover, New Hampshire,⁷ Department of Gynecology and Obstetrics, Women's Health Clinic, Medical University of Vienna, Vienna, Austria,⁸ Department of Obstetrics and Gynecology, University of Hong Kong, Hong Kong, People's Republic of China,⁹ Departments of Family Medicine and of Obstetrics and Gynecology, Medical College of Georgia, Augusta, Georgia,¹⁰ Merck Research Laboratories, West Point, Pennsylvania,¹¹

Received 19 December 2006/ Returned for modification 27 February 2007/ Accepted 2 April 2007

The incorporation of multiple antigens into a single human papillomavirus (HPV) vaccine may induce immune interference. To evaluate whether interference occurs when HPV type 16 (HPV16) virus-like particles are combined in a multivalent vaccine, we conducted a study to evaluate anti-HPV16 responses among subjects receiving three-dose regimens of either a monovalent HPV16 vaccine or a quadrivalent HPV (types 6, 11, 16, and 18) vaccine.

Published ahead of print on 11 April 2007.

A listing of investigators can be found in the acknowledgments.