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Clinical and Vaccine Immunology, May 2007, p. 638-640, Vol. 14, No. 5
1071-412X/07/$08.00+0     doi:10.1128/CVI.00479-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Histoplasmosis-Associated Cross-Reactivity in the BioRad Platelia Aspergillus Enzyme Immunoassay

MiraVista Diagnostics, Indianapolis, Indiana,¹ National Cancer Institute, Pediatric Oncology Branch, Immunocompromised Host Section, CRC, Rm. 1W-5750, 10 Center Drive, Bethesda, Maryland 20892-1100,² Laboratory Animal Sciences Program, SAIC-Frederick, Inc., Frederick, Maryland 21702,³ Indiana University School of Medicine, Department of Pulmonary Medicine, Roudebush Veterans' Administration Hospital, 1481 West Tenth Street, Indianapolis, Indiana 46202⁴

Received 19 December 2006/ Returned for modification 24 January 2007/ Accepted 8 February 2007

We observed false-positive results in the Platelia Aspergillus enzyme-linked immunoassay (EIA) for specimens from patients with histoplasmosis and mice with experimental infection. Platelia Aspergillus EIA-positive specimens were negative in the second-generation Histoplasma antigen EIA. Care must be taken to exclude histoplasmosis for patients with positive Platelia Aspergillus EIA results.

Published ahead of print on 7 March 2007.

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