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Clinical and Vaccine Immunology, April 2007, p. 474-476, Vol. 14, No. 4
1071-412X/07/$08.00+0     doi:10.1128/CVI.00458-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

T-Cell Recognition of Paracoccidioides brasiliensis gp43-Derived Peptides in Patients with Paracoccidioidomycosis and Healthy Individuals{triangledown}

Leo Kei Iwai,1,3,5,{dagger} Márcia Yoshida,4 Aya Sadahiro,4 Washington Robert da Silva,1 Maria Lucia Marin,1,3 Anna Carla Goldberg,1,3,{ddagger} Maria Aparecida Juliano,5 Luiz Juliano,5 Maria Aparecida Shikanai-Yasuda,4 Jorge Kalil,1,2,3 Edecio Cunha-Neto,1,2,3 and Luiz R. Travassos6*

Laboratory of Immunology, Heart Institute (InCor),1 Division of Clinical Immunology and Allergy,2 Institute for Investigations in Immunology, Millennium Institutes, São Paulo, Brazil,3 Department of Infectious and Parasitic Diseases, University of São Paulo Medical School, São Paulo, Brazil,4 Department of Biophysics,5 Discipline of Cell Biology, Department of Microbiology, Immunology and Parasitology, Federal University of São Paulo, UNIFESP, São Paulo, Brazil6

Received 6 December 2006/ Returned for modification 5 January 2007/ Accepted 13 February 2007

Vaccines with synthetic peptides induce the immune response to epitopes that bind to several HLA alleles. By using a TEPITOPE algorithm, we selected and analyzed the T-cell responses of peripheral blood mononuclear cells from 29 paracoccidioidomycosis (PCM) patients to peptides of the immunodominant gp43 antigen of Paracoccidioides brasiliensis, the causative agent of PCM.

* Corresponding author. Mailing address: Disciplina de Biologia Celular, Departamento de Microbiologia, Imunologia e Parasitologia, Universidade Federal de São Paulo, Rua Botucatu 862, 8 andar, São Paulo, SP 04023-062, Brazil. Phone: 55-11-50842991. Fax: 55-11-55715877. E-mail: travassos{at}ecb.epm.br

{triangledown} Published ahead of print on 28 February 2007.

{dagger} Present address: Section on Immunology and Immunogenetics, Joslin Diabetes Center, Harvard Medical School, Boston, MA 02215.

{ddagger} Present address: Chemistry Institute, University of São Paulo, São Paulo, Brazil.

Clinical and Vaccine Immunology, April 2007, p. 474-476, Vol. 14, No. 4
1071-412X/07/$08.00+0     doi:10.1128/CVI.00458-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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