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Clinical and Vaccine Immunology, March 2007, p. 288-292, Vol. 14, No. 3
1071-412X/07/$08.00+0     doi:10.1128/CVI.00364-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Cellular Immunity in Adolescents and Adults following Acellular Pertussis Vaccine Administration

Claudius U. Meyer,^1* Fred Zepp,¹ Michael Decker,^2, Martin Lee,³ Swei-Ju Chang,³ Joel Ward,³ Sandra Yoder,⁴ Hugues Bogaert,⁵ and Kathryn M. Edwards⁴

Pediatric Immunology and Infectious Diseases, Children's Hospital, Johannes Gutenberg University of Mainz, Mainz, Germany,¹ Department of Preventive Medicine, School of Medicine, Vanderbilt University, Nashville, Tennessee,² Harbor-UCLA, Torrance, California,³ Division of Infectious Diseases, Department of Pediatrics, School of Medicine, Vanderbilt University, Nashville, Tennessee,⁴ GlaxoSmithKline, Rixensart, Belgium⁵

Received 5 October 2006/ Returned for modification 16 November 2006/ Accepted 16 January 2007

Cell-mediated immune (CMI) responses to an acellular pertussis vaccine administered to 49 subjects, a subset of participants in the National Institutes of Health-funded adult acellular pertussis vaccine efficacy trial, were evaluated and compared with antibody responses to vaccine antigens. Levels of proliferation of and cytokine secretion from lymphocytes cultured in the presence of pertussis toxin, filamentous hemagglutinin, or pertactin were measured before vaccination and 1 month and 1 year after vaccination. Statistically significant increases in lymphocyte stimulation indices and cytokine secretion were noted at both 1 month and 1 year after vaccination. Brisk pertussis antigen-specific immunoglobulin G responses were also noted at 1 month after vaccination, but these responses had declined by nearly 50% at 1 year after vaccination. These studies clearly demonstrate that both cellular and humoral immune responses occur after the administration of acellular pertussis vaccines to adolescents and adults but that the CMI responses are of greater magnitude and longer duration. CMI responses may be a better correlate of long-term protection.

Published ahead of print on 31 January 2007.

Present address: Sanofi-Pasteur, Swiftwater, PA.