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Clinical and Vaccine Immunology, February 2007, p. 204-207, Vol. 14, No. 2
1071-412X/07/$08.00+0     doi:10.1128/CVI.00179-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Protective Effect of Human Heat Shock Protein 60 Suggested by Its Association with Decreased Seropositivity to Pathogens

Department of Epidemiology and Public Health,¹ Division of Microbial Diseases, UCL Eastman Dental Institute, University College London, London, United Kingdom,² Department of Molecular Biology, Umeå University, Umeå, Sweden,³ Medical Microbiology, Department of Cellular and Molecular Medicine, St. George's, University of London, London, United Kingdom⁴

Received 17 May 2006/ Returned for modification 1 September 2006/ Accepted 7 December 2006

The presence of heat shock protein 60 (Hsp60) in human plasma has been linked with cardiovascular disease (CVD). In this study, the examination of the relationship between Hsp60 in plasma and seropositivity for three microbial agents, which are thought to be risk factors for CVD, surprisingly revealed a negative association between Hsp60 and seropositivity, suggesting a protective effect of this circulating stress protein.

Published ahead of print on 3 January 2007.