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Clinical and Vaccine Immunology, February 2007, p. 115-122, Vol. 14, No. 2
1071-412X/07/$08.00+0     doi:10.1128/CVI.00247-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Relationship between HLA Polymorphisms and Gamma Interferon and Interleukin-10 Cytokine Production in Healthy Individuals after Rubella Vaccination{triangledown}

Inna G. Ovsyannikova,1 Robert M. Jacobson,1,2 Jenna E. Ryan,1 Neelam Dhiman,1 Robert A. Vierkant,3 and Gregory A. Poland1,4,5*

Mayo Vaccine Research Group,1 Department of Pediatric and Adolescent Medicine,2 Division of Biostatistics,3 Program in Translational Immunovirology and Biodefense,4 Department of Internal Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota 559055

Received 5 July 2006/ Returned for modification 20 November 2006/ Accepted 19 December 2006

We studied the association between HLA alleles and rubella-specific gamma interferon (IFN-{gamma}) (Th1) and interleukin-10 (IL-10) (Th2) cytokine responses among 106 healthy children (ages, 14 to 17 years) previously immunized with two doses of rubella vaccine. Antibody titers and cytokine responses to rubella vaccination were not sex or age dependent. Several class I HLA-A (*0201, *2402, *6801) alleles were significantly associated with rubella vaccine-induced IFN-{gamma} secretion. Several class II HLA-DRB1 (*0101) and HLA-DQB1 (*0501) alleles were also suggestive of an association with IFN-{gamma} secretion. Alleles with potential associations with rubella-specific IL-10 production included HLA-A (*0201, *6801), HLA-B (*4901), and HLA-DRB1 (*1302). The class I A*0201 and A*6801 alleles were associated with both IFN-{gamma} and IL-10 secretion. These tentative associations need to be validated in larger studies with subjects of differing ethnicities. These results provide additional evidence that HLA genes may influence Th1- and Th2-specific cytokine response(s) following rubella immunization, which in turn can influence both cellular and humoral immune responses to rubella vaccination.

* Corresponding author. Mailing address: Mayo Vaccine Research Group, Mayo Clinic, Guggenheim 611C, 200 First Street S.W., Rochester, MN 55905. Phone: (507) 284-4968. Fax: (507) 266-4716. E-mail: poland.gregory{at}mayo.edu.

{triangledown} Published ahead of print on 10 January 2007.

Clinical and Vaccine Immunology, February 2007, p. 115-122, Vol. 14, No. 2
1071-412X/07/$08.00+0     doi:10.1128/CVI.00247-06
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





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