This Article Full Text Full Text (PDF) Other Versions of this Article: CVI.00365-07v1 14/12/1652    most recent Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Speare, D. J. Articles by Guselle, N. J. Search for Related Content PubMed PubMed Citation Articles by Speare, D. J. Articles by Guselle, N. J.

Development of an Effective Whole-Spore Vaccine To Protect against Microsporidial Gill Disease in Rainbow Trout (Oncorhynchus mykiss) by Using a Low-Virulence Strain of Loma salmonae

Department of Pathology and Microbiology, Atlantic Veterinary College, University of Prince Edward Island, Charlottetown, Prince Edward Island, Canada C1A 4P3

Received 5 September 2007/ Returned for modification 2 October 2007/ Accepted 7 October 2007

In determining the effective vaccine spore dose of a low-virulence strain of Loma salmonae to limit microsporidial gill disease in trout, we found that fish receiving 10³ to 10⁵ killed spores had the best protection against experimental infection, with 85% fewer xenomas in their gills than in the controls. Intraperitoneal delivery of the vaccine was effective, and the addition of adjuvant did not improve vaccine performance against this disease-causing microsporidian.

Published ahead of print on 17 October 2007.