CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Other Versions of this Article:
CVI.00298-07v1
14/11/1532    most recent
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by Iannacone, M.
Right arrow Articles by Guidotti, L. G.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Iannacone, M.
Right arrow Articles by Guidotti, L. G.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, November 2007, p. 1532-1535, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00298-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.

Antiplatelet Drug Therapy Moderates Immune-Mediated Liver Disease and Inhibits Viral Clearance in Mice Infected with a Replication-Deficient Adenovirus{triangledown}

Matteo Iannacone,1,2 Giovanni Sitia,2 Iñigo Narvaiza,3 Zaverio M. Ruggeri,1 and Luca G. Guidotti1,2*

Department of Molecular and Experimental Medicine, the Scripps Research Institute, 10550 North Torrey Pines Rd., La Jolla, California 92037,1 Immunopathogenesis of Liver Infections Unit, San Raffaele Scientific Institute, Via Olgettina 58, Milan 20132, Italy,2 Infectious Disease Laboratory, the Salk Institute for Biological Studies, 10010 North Torrey Pines Rd., La Jolla, California 920373

Received 12 June 2007/ Accepted 3 September 2007

Treatment with a low dose of combined aspirin and clopidogrel, two antiplatelet drugs widely used in humans, markedly reduced the homing of virus-specific cytotoxic T lymphocytes and virus-nonspecific inflammatory leukocytes to the liver of mice acutely infected with a hepatotropic, replication-deficient, lacZ-expressing adenovirus (RAd35). Consequently, aspirin/clopidogrel-induced platelet dysfunction greatly diminished liver disease severity and inhibited viral clearance. Along with the finding that aspirin/clopidogrel caused neither bleeding nor anemia, our results suggest that antiplatelet drugs may be considered to limit excessive liver immunopathology and/or to facilitate the persistence of hepatotropic viral vectors utilized in gene therapy.

* Corresponding author. Mailing address: Scripps Research Institute, Department of Molecular and Experimental Medicine, 10550 North Torrey Pines Rd., La Jolla, CA 92037. Phone: (858) 784-2758. Fax: (858) 784-2960. E-mail: guidotti{at}scripps.edu

{triangledown} Published ahead of print on 19 September 2007.

Clinical and Vaccine Immunology, November 2007, p. 1532-1535, Vol. 14, No. 11
1071-412X/07/$08.00+0     doi:10.1128/CVI.00298-07
Copyright © 2007, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2007 by the American Society for Microbiology. All rights reserved.