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 Previous Article

Clinical and Vaccine Immunology, September 2006, p. 1064-1069, Vol. 13, No. 9
1071-412X/06/$08.00+0     doi:10.1128/CVI.00178-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Characterization of a Phenotypically Unique Population of CD13+ Dendritic Cells Resident in the Spleen

Yan Zhuang,1 Waithaka Mwangi,1,{dagger} Wendy C. Brown,1 William C. Davis,1 Jayne C. Hope,2 and Guy H. Palmer1*

Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, Washington,1 Institute of Animal Health, Compton, Newbury, Berkshire, United Kingdom2

Received 16 January 2006/ Returned for modification 21 June 2006/ Accepted 26 July 2006

Immature dendritic cells (DCs) resident in bovine spleens represent a distinct CD11a+ CD11c+ CD13+ CD172+ CD205+ population compared to those circulating in peripheral blood or trafficking via afferent lymph. Upon cytokine-induced maturation, splenic DCs both efficiently present antigen in the stimulation of allogeneic lymphocyte proliferation and recall antigen-specific responses.

* Corresponding author. Mailing address: Department of Veterinary Microbiology and Pathology, Washington State University, Pullman, WA 99164-7040. Phone: (509) 335-6033. Fax: (509) 335-8529. E-mail: gpalmer{at}vetmed.wsu.edu.

{dagger} Present address: Department of Veterinary Pathobiology, College of Veterinary Medicine & Biomedical Sciences, Texas A&M University, College Station, TX 77843.

Clinical and Vaccine Immunology, September 2006, p. 1064-1069, Vol. 13, No. 9
1071-412X/06/$08.00+0     doi:10.1128/CVI.00178-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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Copyright © 2006 by the American Society for Microbiology. All rights reserved.