CVI
Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
This Article
Right arrow Full Text
Right arrow Full Text (PDF)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Download to citation manager
Right arrowReprints and Permissions
Right arrow Copyright Information
Right arrow Books from ASM Press
Right arrow MicrobeWorld
Citing Articles
Right arrow Citing Articles via Google Scholar
Google Scholar
Right arrow Articles by van der Graaf, C. A. A.
Right arrow Articles by Kullberg, B. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by van der Graaf, C. A. A.
Right arrow Articles by Kullberg, B. J.

 Previous Article  |  Next Article 

Clinical and Vaccine Immunology, March 2006, p. 423-425, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.423-425.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Nucleotide Oligomerization Domain 2 (Nod2) Is Not Involved in the Pattern Recognition of Candida albicans

Chantal A. A. van der Graaf,1,3 Mihai G. Netea,1,3 Barbara Franke,2 Stephen E. Girardin,4 Jos W. M. van der Meer,1,3 and Bart Jan Kullberg1,3*

Departments of Medicine,1 Human Genetics, Radboud University Nijmegen Medical Center,2 Nijmegen University Center for Infectious Diseases, Nijmegen, The Netherlands,3 Unité de Pathogénie Microbienne Moleculaire, Institut Pasteur, Paris, France4

Received 10 September 2005/ Returned for modification 18 October 2005/ Accepted 20 December 2005

Nucleotide-binding oligomerization domain 2 (Nod2) pathways are known to interact with Toll-like receptor 2 (TLR2) and TLR4, which are pattern recognition receptors for Candida albicans. We observed that the prevalence of Nod2 polymorphisms was not increased in patients with Candida infections. Candida-induced cytokine production in individuals with Nod2 polymorphisms was unaffected. We conclude that Nod2 is unlikely to play an important role in the recognition of Candida albicans.

* Corresponding author. Mailing address: Department of Medicine (463), Radboud University Nijmegen Medical Center, P.O. Box 9101, 6500 HB Nijmegen, The Netherlands. Phone: 31(24)3668015. Fax: 31(24)3541734. E-mail: B.Kullberg{at}aig.umcn.nl.

Clinical and Vaccine Immunology, March 2006, p. 423-425, Vol. 13, No. 3
1071-412X/06/$08.00+0     doi:10.1128/CVI.13.3.423-425.2006
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





Home Help [Feedback] [For Subscribers] [Archive] [Search] [Contents]
Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 2006 by the American Society for Microbiology. All rights reserved.