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Clinical and Vaccine Immunology, November 2006, p. 1296-1298, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00206-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Association of Selective HLA Class II Susceptibility-Conferring and Protective Haplotypes with Type 2 Diabetes in Patients from Bahrain and Lebanon{triangledown}

Wassim Y. Almawi,1* Saria F. Wakim-Ghorayeb,2 Mona R. Arekat,3 Pierre Najm,2 Sose H. Keleshian,4 Nasreen Al-Sayed,3 Bruno Blanchon,3 Hanady R. Samaha,2 and Noha Irani-Hakime2

College of Medicine and Medical Sciences, Arabian Gulf University, Manama, Bahrain,1 St. Georges University Hospital, Beirut, Lebanon,2 Joslin Diabetes Center-Bahrain, Manama, Bahrain,3 Haigazian University, Beirut, Lebanon4

Received 3 June 2006/ Returned for modification 17 July 2006/ Accepted 12 September 2006

The association of HLA class II with type 2 diabetes (T2DM) was investigated in Bahraini and Lebanese subjects. DRB1*070101 (Lebanese and Bahraini) and DQB1*0201 (Lebanese) were susceptibility-conferring alleles, and unique susceptibility-conferring/protective haplotypes were found in both patient groups. Regression analysis confirmed that DRB1*070101-DQB1*0201 (Bahraini) and DRB1*110101-DQB1*0201 (Lebanese) were susceptibility-conferring haplotypes.

* Corresponding author. Mailing address: Department of Medical Biochemistry, College of Medicine and Medical Sciences, Arabian Gulf University, P.O. Box 22979, Manama, Bahrain. Phone: 973-39717118. Fax: 973-17271090. E-mail: wyalmawi{at}yahoo.co.uk.

{triangledown} Published ahead of print on 20 September 2006.

Clinical and Vaccine Immunology, November 2006, p. 1296-1298, Vol. 13, No. 11
1071-412X/06/$08.00+0     doi:10.1128/CVI.00206-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.





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