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Clinical and Vaccine Immunology, October 2006, p. 1162-1165, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00099-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.

Analysis of Antibody Response in Humans to the Type A OspC Loop 5 Domain and Assessment of the Potential Utility of the Loop 5 Epitope in Lyme Disease Vaccine Development

Eric L. Buckles,1 Christopher G. Earnhart,1 and Richard T. Marconi1,2*

Department of Microbiology and Immunology,1 Center for the Study of Biological Complexity, Medical College of Virginia at Virginia Commonwealth University, Richmond, Virginia 23298-06782

Received 14 March 2006/ Returned for modification 31 May 2006/ Accepted 27 July 2006

The OspC protein of Borrelia burgdorferi is an immunodominant antigen. Here we demonstrate that the loop 5 domain of type A OspC is surface exposed, elicits bactericidal antibody in mice, and is antigenic in humans. The data suggest that loop 5 may be suitable for inclusion in a polyvalent, chimeric OspC vaccinogen.

* Corresponding author. Mailing address: Department of Microbiology and Immunology, Medical College of Virginia at Virginia Commonwealth University, 1112 E. Clay St., McGuire Hall, Richmond, VA 23298-0678. Phone: (804) 828-3779. Fax: (804) 828-9946. E-mail: rmarconi{at}hsc.vcu.edu.

Clinical and Vaccine Immunology, October 2006, p. 1162-1165, Vol. 13, No. 10
1071-412X/06/$08.00+0     doi:10.1128/CVI.00099-06
Copyright © 2006, American Society for Microbiology. All Rights Reserved.



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