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Patients with Pulmonary Tuberculosis Develop a Strong Humoral Response against Methylated Heparin-Binding Hemagglutinin

Department of Biomedical Sciences,¹ Institute of Infectious Diseases,² Institute of Respiratory Diseases, University of Sassari, Sassari, Italy,³ Department of Experimental Pathology and Biotechnology, University of Pisa, Pisa, Italy,⁴ Institute of Tisiology, Azienda Sanitaria Locale no. 3 of Nuoro, Nuoro, Italy,⁵ Institute of Microbiology, Catholic University, Rome, Italy⁶

Received 17 May 2005/ Returned for modification 31 May 2005/ Accepted 13 July 2005

Reactivities of human sera against selected recombinant Mycobacterium tuberculosis antigens were assessed by enzyme-linked immunosorbent assay. The results obtained indicate that patients with tuberculosis (TB) do not develop a strong humoral response against PE_PGRS and PPE proteins or against the Ag85B and heparin-binding hemagglutinin (HBHA) recombinant antigens. Conversely, purified methylated HBHA was strongly recognized by sera obtained from TB patients compared to controls.

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