This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Kremer, J. R. Articles by Muller, C. P. Search for Related Content PubMed PubMed Citation Articles by Kremer, J. R. Articles by Muller, C. P.

Evaluation of Commercial Assay Detecting Specific Immunoglobulin G in Oral Fluid for Determining Measles Immunity in Vaccinees

Institute of Immunology and WHO Collaborative Centre for Measles and WHO European Regional Reference Laboratory for Measles and Rubella, Laboratoire National de Santé, L-1011 Luxembourg

Received 16 December 2004/ Returned for modification 14 January 2005/ Accepted 23 February 2005

A commercial assay for detection of measles immunoglobulin G (IgG) in oral fluid was evaluated in a highly vaccinated cohort using serum IgG as gold standard. In contrast to previous studies from cohorts protected by natural immunity, antibody prevalence was significantly underestimated (–7.4%; confidence interval: –1.5 to –13.2%; P = 0.01) due to a reduced sensitivity when antibody levels were low.