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Relationship between Intracranial Granulomas and Cerebrospinal Fluid Levels of Gamma Interferon and Interleukin-10 in Patients with Tuberculous Meningitis

Adel M. Mansour,¹ Robert W. Frenck Jr.,^1* Toni Darville,² Isabelle A. Nakhla,¹ Thomas F. Wierzba,^1, Yehia Sultan,³ Magdy I. Bassiouny,^4, Kathryn McCarthy,² and Richard F. Jacobs²

University of Arkansas for Medical Sciences, Little Rock, Arkansas,² U.S. Naval Medical Research Unit No. 3,¹ Ministry of Health and Population,³ Abbassia Fever Hospital, Cairo, Egypt⁴

Received 26 August 2004/ Returned for modification 7 October 2004/ Accepted 14 December 2004

Cerebrospinal fluid gamma interferon (IFN-) and interleukin-10 levels in 39 patients with tuberculous meningitis were serially measured. Cytokine levels did not predict intracranial granuloma (IG) development, but IFN- levels in the top quartile after 1 month of therapy were highly associated (odds ratio = 18) with detection of an IG by computed tomography scanning.

Present address: EPI and Polio Eradication, World Health Organization, Kathmandu, Nepal.

Present address: School of Medicine, Cairo University, Cairo, Egypt.