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Clinical and Diagnostic Laboratory Immunology, February 2005, p. 354-358, Vol. 12, No. 2
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.2.354-358.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Antigens of Mycobacterium tuberculosis Recognized by Antibodies during Incipient, Subclinical Tuberculosis

Krishna K. Singh,1 Yuxin Dong,1 John T. Belisle,2 Jeffrey Harder,2 Vijay K. Arora,3 and Suman Laal1,4*

Department of Pathology, New York University School of Medicine,1 New York Harbor Health Care System, New York, New York,4 Department of Microbiology, Immunology and Pathology, Mycobacteria Research Laboratories, Colorado State University, Fort Collins, Colorado,2 Lala Ram Sarup Institute of Tuberculosis and Respiratory Diseases, New Delhi, India3

Received 12 October 2004/ Returned for modification 18 November 2004/ Accepted 9 December 2004

Serum samples obtained from human immunodeficiency virus (HIV)-infected tuberculosis (TB) patients months prior to clinical TB were used to delineate the profile of Mycobacterium tuberculosis culture filtrate proteins recognized during subclinical TB. A subset of ~12 antigens was recognized by antibodies in these serum samples. Antibodies to two of these antigens (81 [88]-kDa malate synthase [GlcB] and MPT51) were present in serum samples obtained during incipient subclinical TB in 19 (~90%) of the 21 HIV-infected TB patients tested. These antigens will be useful for devising diagnostic tests that can identify HIV-positive individuals who are at a high risk for developing clinical TB.

* Corresponding author. Mailing address: Veterans Affairs Medical Center, Room 18123 North, 423 East 23rd St., New York, NY 10010. Phone: (212) 263-4152. Fax: (212) 951-6321. E-mail: suman.laal{at}med.nyu.edu.

Clinical and Diagnostic Laboratory Immunology, February 2005, p. 354-358, Vol. 12, No. 2
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.2.354-358.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.



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