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Serological Markers (Anti-Saccharomyces cerevisiae Mannan Antibodies and Antineutrophil Cytoplasmic Antibodies) in Inflammatory Bowel Disease: Diagnostic Utility and Phenotypic Correlation

Department of Clinical Immunology, St. Bartholomew's, London, United Kingdom,¹ Department of Adult and Paediatric Gastroenterology, Barts, and The London School of Medicine and Dentistry, London, United Kingdom²

Received 4 August 2005/ Returned for modification 6 September 2005/ Accepted 8 September 2005

We have evaluated the utility of antineutrophil cytoplasmic antibodies and anti-Saccharomyces cerevisiae mannan antibodies for distinguishing Crohn's disease from ulcerative colitis and other diarrheal illnesses by evaluating sera from 396 patients. Sensitivity, specificity, and phenotypic correlations were investigated. The implications of our findings for implementing these tests in routine clinical testing are discussed.