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Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1254-1256, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1254-1256.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.

Critical Investigation of the CD14 Promoter Polymorphism: Lack of a Role for In Vitro Cytokine Response and Membrane CD14 Expression

Sonja von Aulock,1 Jan Rupp,2 Katja Gueinzius,1 Matthias Maass,2 and Corinna Hermann1*

Biochemical Pharmacology, University of Konstanz, Konstanz, Germany,1 Institute of Medical Microbiology and Hygiene, University of Luebeck, Luebeck, Germany2

Received 2 February 2005/ Returned for modification 3 May 2005/ Accepted 18 May 2005

Blood of volunteers, genotyped for the CD14 C(–159)->T polymorphism, showed no difference in cytokine release when stimulated with nine CD14-dependent immune stimuli. An analysis of the published data on the proposed association of CD14 genotype with membrane CD14 density revealed no significant correlation, questioning a functional impact of the CD14 polymorphism.

* Corresponding author. Mailing address: Biochemical Pharmacology, University of Konstanz, P.O. Box M655, 78457 Konstanz, Germany. Phone: 49 7531 884524. Fax: 49 7531 884156. E-mail: Corinna.hermann{at}uni-konstanz.de.

Clinical and Diagnostic Laboratory Immunology, October 2005, p. 1254-1256, Vol. 12, No. 10
1071-412X/05/$08.00+0     doi:10.1128/CDLI.12.10.1254-1256.2005
Copyright © 2005, American Society for Microbiology. All Rights Reserved.





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