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Humoral and Cellular Immunity in Children with Mycoplasma pneumoniae Infection: a 1-Year Prospective Study

Iwona Stelmach,^1* Malgorzata Podsiadowicz-Borzcka,¹ Tomasz Grzelewski,¹ Pawel Majak,¹ Wlodzimierz Stelmach,² Joanna Jerzyska,¹ Marta Popawska,³ and Jaroslaw Dziadek³

M. Curie Hospital, Department of Pediatrics and Allergy, Zgierz, Poland,¹ Regional Health Insurance Fund, Lodz, Poland,² Center for Medical Biology, Polish Academy of Sciences, Lodz, Poland³

Received 1 April 2005/ Returned for modification 18 June 2005/ Accepted 25 July 2005

To determine whether children have persistent abnormalities in cellular and humoral immunity development after acute Mycoplasma pneumoniae infection, serum immunoglobulin G (IgG), IgA, IgM, and IgE levels and lymphocyte phenotypes were determined. There were no changes in the levels of IgG, IgM, IgA, or CD4⁺ or CD19⁺ lymphocytes that were measured in M. pneumoniae-positive patients after 3 months or after 12 months, but there were increases in these in M. pneumoniae-negative patients. Serum IgE increased in M. pneumoniae-positive patients. We have shown alterations in immunity development after M. pneumoniae infection.