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Clinical and Diagnostic Laboratory Immunology, September 2004, p. 909-912, Vol. 11, No. 5
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.5.909-912.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Comparison of Oral Fluid Collectors for Use in a Rapid Point-of-Care Diagnostic Device

Carol Holm-Hansen,1 Gary Tong,2 Cheryl Davis,2 William R. Abrams,3 and Daniel Malamud2*

Division for Infectious Disease Control, Norwegian Institute of Public Health, Oslo, Norway,1 Department of Biochemistry,2 School of Dental Medicine, Department of Anatomy and Cell Biology, University of Pennsylvania, Philadelphia, Pennsylvania3

Received 24 February 2004/ Returned for modification 2 April 2004/ Accepted 13 May 2004

Orally based diagnostic testing is emerging as an alternative, noninvasive method for analyzing a variety of analytes. These analytes include pathogens, antibodies, drugs, and nucleic acids. In the present study we developed a protocol for evaluation of collectors that could be used in orally based, point-of-care diagnostics. A performance comparison was carried out with a number of commercially available collectors, and their ability to deliver fluid, proteins, bacteria, and nucleic acid from pathogens compatible with PCR was assessed. The collectors were all capable of picking up and delivering test materials, albeit at various levels.

* Corresponding author. Mailing address: Department of Biochemistry, University of Pennsylvania School of Dental Medicine, 240 South 40th St., Philadelphia, PA 19104-6030. Phone: (215) 898-6576. Fax: (215) 898-3695. E-mail: malamud{at}pobox.upenn.edu.

Clinical and Diagnostic Laboratory Immunology, September 2004, p. 909-912, Vol. 11, No. 5
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.5.909-912.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Copyright © 2004 by the American Society for Microbiology. All rights reserved.