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Clinical and Diagnostic Laboratory Immunology, July 2004, p. 792-794, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.792-794.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.

Kinetics of Severe Acute Respiratory Syndrome (SARS) Coronavirus-Specific Antibodies in 271 Laboratory-Confirmed Cases of SARS

Zhongping He,1,2* Qingming Dong,1 Hui Zhuang,2 Shujing Song,1 Guoai Peng,1 Guangxiang Luo,3 and Dominic E. Dwyer4

Beijing Ditan Hospital, Beijing 100011,1 Department of Microbiology, Peking University Health Science Center, Beijing 100083, People's Republic of China,2 Department of Microbiology, Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky 40536-0298,3 Centre for Infectious Diseases and Microbiology Laboratory Services, Institute of Clinical Pathology and Medical Research, Westmead Hospital, Westmead, New South Wales 2145, Australia4

Received 22 November 2003/ Returned for modification 12 January 2004/ Accepted 9 April 2004

The sensitivities and specificities of an immunofluorescence assay and an enzyme immunoassay for detection of antibodies specific for severe acute respiratory syndrome coronavirus (SARS-CoV) were compared for 148 laboratory-confirmed SARS cases. The appearance and persistence of SARS-CoV-specific antibodies were assessed, with immunoglobulin G detected in 59% of samples collected within 14 days and persisting for 60 to 95 days after the onset of illness.

* Corresponding author. Mailing address: Department of Microbiology, Peking University Health Science Center, Beijing 100083, People's Republic of China. Phone: 86-10-82801617. Fax: 86-10-82802221. E-mail: zhongpinghe{at}yahoo.com.

Clinical and Diagnostic Laboratory Immunology, July 2004, p. 792-794, Vol. 11, No. 4
1071-412X/04/$08.00+0     DOI: 10.1128/CDLI.11.4.792-794.2004
Copyright © 2004, American Society for Microbiology. All Rights Reserved.



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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
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Copyright © 2004 by the American Society for Microbiology. All rights reserved.