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Clinical and Diagnostic Laboratory Immunology, September 2003, p. 741-743, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.741-743.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

High Levels of Interleukin-1 in Patients with Endemic Pemphigus Foliaceus

Denise Bertulucci Rocha-Rodrigues,1,2 Giovana Paschoini,1 Sanivia Aparecida Lima Pereira,1,2 Marlene Antonia dos Reis,1 Vicente de Paula Antunes Teixeira,1 and Virmondes Rodrigues Jr.1*

Faculdade de Medicina do Triângulo Mineiro,1 Universidade de Uberaba, Uberaba, Minas Gerais, Brazil2

Received 10 December 2002/ Returned for modification 4 February 2003/ Accepted 26 June 2003

Endemic pemphigus foliaceus (EPF) is an autoimmune disease characterized by blister formation with a loss of cohesion and infiltration of inflammatory cells. We observed that supernatants of peripheral blood mononuclear cells from patients produced significantly more interleukin-1ß (IL-1ß) than those from stimulated healthy controls. Furthermore, a Th2 bias was observed in EPF patients when the IL-5/gamma interferon ratio was analyzed. These results indicate that cells from pemphigus patients react with a vigorous proinflammatory response.

* Corresponding author. Mailing address: Faculdade de Medicina do Triângulo Mineiro, Laboratory of Immunology, 30, Frei Paulino, Uberaba, Minas Gerais 38025-180, Brazil. Phone: 55 34 3318 52 89. Fax: 55 34 3318 56 51. E-mail: vrodrigues{at}mednet.com.br.

Clinical and Diagnostic Laboratory Immunology, September 2003, p. 741-743, Vol. 10, No. 5
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.5.741-743.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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Copyright © 2003 by the American Society for Microbiology. All rights reserved.