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Clinical and Diagnostic Laboratory Immunology, May 2003, p. 495-497, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.495-497.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Activation of Coagulation by Administration of Recombinant Factor VIIa Elicits Interleukin 6 (IL-6) and IL-8 Release in Healthy Human Subjects

Evert de Jonge,1* Philip W. Friederich,2 George P. Vlasuk,3 William E. Rote,3 Margaretha B. Vroom,1 Marcel Levi,2 and Tom van der Poll2,4

Departments of Intensive Care,1 Internal Medicine,2 Laboratory of Experimental Internal Medicine, Academic Medical Center, University of Amsterdam, The Netherlands,4 Corvas International, San Diego, California3

Received 18 July 2002/ Returned for modification 16 December 2002/ Accepted 21 January 2003

The activation of coagulation has been shown to contribute to proinflammatory responses in animal and in vitro experiments. Here we report that the activation of coagulation in healthy human subjects by the administration of recombinant factor VIIa also elicits a small but significant increase in the concentrations of interleukin 6 (IL-6) and IL-8 in plasma. This increase was absent when the subjects were pretreated with recombinant nematode anticoagulant protein c2, the inhibitor of tissue factor-factor VIIa.

* Corresponding author. Mailing address: Department of Intensive Care, Academic Medical Center, P.O. Box 22660, 1100 DD Amsterdam, The Netherlands. Phone: 31 20 5662509. Fax: 31 20 6972988. E-mail: e.dejonge{at}amc.uva.nl.

Clinical and Diagnostic Laboratory Immunology, May 2003, p. 495-497, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.495-497.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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