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Clinical and Diagnostic Laboratory Immunology, May 2003, p. 489-491, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.489-491.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

A Patient with Crimean-Congo Hemorrhagic Fever Serologically Diagnosed by Recombinant Nucleoprotein-Based Antibody Detection Systems

Qing Tang,1 Masayuki Saijo,2 Yuzhen Zhang,3 Muer Asiguma,3 Dong Tianshu,3 Lei Han,1 Bawudong Shimayi,4 Akihiko Maeda,2 Ichiro Kurane,2 and Shigeru Morikawa2*

Second Division of Viral Hemorrhagic Fever, Institute of Infectious Disease Control and Prevention, Chinese Center for Disease Control and Prevention, Beijing 102206,1 Xinjiang Bachu County People's Hospital,3 Bachu County Center for Disease Control and Prevention, Bachu County, Kashi District, Xinjiang Autonomous Region, People's Republic of China,4 Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, Musashimurayama, Tokyo 208-0011, Japan2

Received 23 October 2002/ Returned for modification 6 February 2003/ Accepted 25 February 2003

We treated a male patient with Crimean-Congo hemorrhagic fever (CCHF). The diagnosis of CCHF was confirmed by reverse transcription-PCR and recombinant nucleoprotein (rNP)-based immunoglobulin G (IgG) and IgM capture enzyme-linked immunosorbent assays of serially collected serum samples. The patient was treated with intravenous ribavirin and recovered with no consequences. The study indicates that rNP-based CCHF virus antibody detection systems are useful for confirming CCHF virus infections. This case also suggests that intravenous ribavirin therapy may be promising for the treatment of CCHF patients.

* Corresponding author. Mailing address: Special Pathogens Laboratory, Department of Virology 1, National Institute of Infectious Diseases, 4-7-1 Gakuen, Musashimurayama, Tokyo 208-0011, Japan. Phone: 81-42-561-0771, ext. 791. Fax: 81-42-561-2039. E-mail: morikawa{at}nih.go.jp.

Clinical and Diagnostic Laboratory Immunology, May 2003, p. 489-491, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.489-491.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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