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Bactericidal/Permeability-Increasing Protein Is Expressed by Human Dermal Fibroblasts and Upregulated by Interleukin 4

Department of Rheumatology, University Hospital Luebeck and Rheumaklinik Bad Bramstedt, 24576 Bad Bramstedt,¹ Department of Dermatology, University-Hospital Kiel, 24105 Kiel, Germany²

Received 21 October 2002/ Returned for modification 13 January 2003/ Accepted 3 March 2003

The bactericidal/permeability-increasing protein (BPI) is an antibiotic- and endotoxin-neutralizing protein of granulocytes and epithelial cells. Constitutive expression of BPI, which increases upon interleukin 4 stimulation, by human dermal fibroblast was demonstrated, suggesting an important role of BPI in gram-negative bacterial clearance and a dampened response to endotoxin in the skin.

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