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Clinical and Diagnostic Laboratory Immunology, May 2003, p. 446-450, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.446-450.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Cross-Reactivity between Chlamydia trachomatis Heat Shock Protein 10 and Early Pregnancy Factor

Fotini Betsou,1* Maria José Borrego,2 Nicolas Guillaume,3 Maria Anjos Catry,2 Sandra Romão,4 J. A. Machado-Caetano,4 Jean Marie Sueur,1 Jacques Mention,5 Nicole Faille,3 and Jeanne Orfila1

Biobanque de Picardie, 16 rue Fernel, 80000 Amiens,1 Laboratoire d'Hématologie, Centre Hospitalier Universitaire d'Amiens, Place Victor Pauchet,3 Centre de Gynécologie Obstétrique, Université de Picardie Jules Verne, 80054 Amiens, France,5 Centro de Bacteriologia, Instituto Nacional de Saùde Dr. Ricardo Jorge,2 Serviço de Imunologia, Faculdade de Ciências Médicas, Universidade Nova de Lisboa, Lisbon, Portugal4

Received 2 July 2002/ Returned for modification 23 January 2003/ Accepted 10 March 2003

Chlamydia trachomatis heat shock protein 10 (Chsp10) is associated with chronic genital tract infection with C. trachomatis. Chsp10 is homologous to human chaperonin 10 (Cpn10) and early pregnancy factor (EPF), a form of human Cpn10 that is specifically secreted at the start of pregnancy. We investigated cross-reactions between serum anti-Chsp10 antibodies and anti-EPF antibodies in pregnant and nonpregnant patients. Pregnancy was found to be associated with the presence of anti-EPF antibodies, which are specifically induced in pregnant women with a history of C. trachomatis infection, and with the presence of serum anti-Chsp10 antibodies. We also found that infertility was associated with the presence of anti-Chsp10 and anti-EPF antibodies. The HLA class II haplotype DR8 DQ4 was associated with the presence of anti-Chsp10 antibodies but not of anti-EPF antibodies.

* Corresponding author. Mailing address: Biobanque de Picardie, 16 rue Fernel, 80000 Amiens, France. Phone: 0033322913967. Fax: 0033322916954. E-mail: fay.betsou{at}biobanque-picardie.com.

Clinical and Diagnostic Laboratory Immunology, May 2003, p. 446-450, Vol. 10, No. 3
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.3.446-450.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.





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