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Clinical and Diagnostic Laboratory Immunology, March 2003, p. 332-335, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.332-335.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.

Interleukin 12 in Part Regulates Gamma Interferon Release in Human Whole Blood Stimulated with Leptospira interrogans

Maaike de Fost,1,2 Rudy A. Hartskeerl,3 Martijn R. Groenendijk,3 and Tom van der Poll1,2*

Laboratory of Experimental Internal Medicine,1 Department of Infectious Diseases, Tropical Medicine and AIDS, Academic Medical Center, University of Amsterdam,2 WHO/FAO Collaborating Centre for Reference and Research on Leptospirosis, Royal Tropical Institute, Amsterdam, The Netherlands3

Received 10 September 2002/ Returned for modification 15 October 2002/ Accepted 5 December 2002

Heat-killed pathogenic Leptospira interrogans serovar rachmati induced the production of gamma interferon (IFN-{gamma}) and the IFN-{gamma}-inducing cytokines interleukin-12p40 (IL-12p40) and tumor necrosis factor alpha in human whole blood in vitro. The production of IFN-{gamma} was largely dependent on IL-12. These data establish that pathogenic leptospires can stimulate the production of type I cytokines involved in cellular immunity.

* Corresponding author. Mailing address: Laboratory of Experimental Internal Medicine, Room G2-130, Academic Medical Center, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands. Phone: 31-20-5665910. Fax: 31-20-6977192. E-mail: t.vanderpoll{at}amc.uva.nl.

Clinical and Diagnostic Laboratory Immunology, March 2003, p. 332-335, Vol. 10, No. 2
1071-412X/03/$08.00+0     DOI: 10.1128/CDLI.10.2.332-335.2003
Copyright © 2003, American Society for Microbiology. All Rights Reserved.



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