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Nucleoporin p62 Antibodies in a Case of Mixed Connective Tissue Disease

Medizinische Poliklinik, University of Wurzburg, 97070 Wurzburg, Germany

Received 3 June 2002/ Returned for modification 27 August 2002/ Accepted 13 November 2002

Mixed connective tissue disease is an overlap syndrome characterized by features of different systemic autoimmune diseases and a high titer of U1-snRNP antibodies. We examine here the autoantibodies to nucleoporin p62 in a severe case of mixed connective tissue disease in a young male patient. Thus far, p62 antibodies have mainly been described in cases of primary biliary cirrhosis. We speculate that the presence of p62 antibodies is an indication of a poor prognosis in connective tissue disorders.