This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Copyright Information Books from ASM Press MicrobeWorld Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Akingbade, D. Articles by Brown, D. W. G. Search for Related Content PubMed PubMed Citation Articles by Akingbade, D. Articles by Brown, D. W. G.

Detection of Low-Avidity Immunoglobulin G in Oral Fluid Samples: New Approach for Rubella Diagnosis and Surveillance

Enteric, Respiratory, and Neurological Virus Laboratory, Central Public Health Laboratory, London NW9 5HT, United Kingdom

Received 31 May 2002/ Returned for modification 25 July 2002/ Accepted 11 September 2002

Low-avidity rubella immunoglobulin G (IgG) was detected in oral fluid samples from 30 of 32 rubella IgM-positive patients (sensitivity, 94%) and from 4 of 34 IgM-negative patients (specificity, 88%). Measuring IgG avidity in oral fluid samples could improve the reliability of rubella surveillance when the incidence of the disease and the positive predictive value of IgM tests are low.

This article has been cited by other articles:

• Pannuti, C. S., Morello, R. J., de Moraes, J. C., Curti, S. P., Afonso, A. M. S., Camargo, M. C. C., de Souza, V. A. U. F. (2004). Identification of Primary and Secondary Measles Vaccine Failures by Measurement of Immunoglobulin G Avidity in Measles Cases during the 1997 Sao Paulo Epidemic. CVI 11: 119-122 [Abstract] [Full Text]