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Clinical and Diagnostic Laboratory Immunology, Nov 1994, 744-746, Vol 1, No. 6
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Size variation of the major immunodominant protein of Cowdria ruminantium

AF Barbet, SM Semu, N Chigagure, PJ Kelly, F Jongejan and SM Mahan
Department of Infectious Diseases, University of Florida, Gainesville 32611-0880, USA.

An immunodominant response is made to a polypeptide of approximately 32 kDa in animals infected with the rickettsial pathogen Cowdria ruminantium. We show here using cultured strains of the rickettsia from different geographical areas that the apparent size of this polypeptide varies with strain origin. Changes in the primary structure between strains should be considered in the design of vaccines and diagnostic tests based on this antigen.


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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1994 by the American Society for Microbiology. All rights reserved.