Clinical and Diagnostic Laboratory Immunology, Nov 1994, 737-740, Vol 1, No. 6
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Prevalence in Cryptococcus neoformans strains of a polysaccharide epitope which can elicit protective antibodies

W Cleare, S Mukherjee, ED Spitzer and A Casadevall
Department of Microbiology and Immunology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.

Monoclonal antibody (MAb) 2H1 binds to an epitope in the capsule of Cryptococcus neoformans that can elicit protective antibodies. The binding of MAb 2H1 to C. neoformans strains was studied by agglutination, immunofluorescence, and phagocytosis assays. The MAb 2H1 epitope was present in all 21 isolates studied, including those recovered from patients with recurrent infections.

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