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Clinical and Diagnostic Laboratory Immunology, May 1994, 361-363, Vol 1, No. 3
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Use of zidovudine in human immunodeficiency virus-induced hepatitis

DL Wertheim, E Valderamma and VR Bonagura
Division of Allergy and Immunology, Schneider Children's Hospital, New Hyde Park, New York 11042, USA.

Hepatitis is a common complication of human immunodeficiency virus (HIV) disease in children. Often a distinct pathogen cannot be identified. Therefore, by exclusion, one must consider HIV the direct pathogen. Zidovudine (AZT) has not been used as a treatment for HIV- positive children with presumed HIV-induced hepatitis because of the potential of this medication to exacerbate preexisting hepatitis. We have used AZT to treat an 8-month-old female with severe HIV-induced hepatitis and have achieved complete remission with this regimen. For some HIV-positive children with HIV-induced hepatitis, AZT may be the drug of choice to resolve hepatic inflammation caused by this virus.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1994 by the American Society for Microbiology. All rights reserved.