Clinical and Diagnostic Laboratory Immunology, 05 1994, 357-360, Vol 1, No. 3
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis

VR Bonagura, FP Siegal, AL Abramson, F Santiago-Schwarz, ME O'Reilly, K Shah, D Drake and BM Steinberg
Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, New York 11042, USA.

Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.

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