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Clinical and Diagnostic Laboratory Immunology, May 1994, 353-356, Vol 1, No. 3
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Analysis of tuberculous meningitis cases by an immunoblotting assay based on a mycobacterial antigen complex

YL Zou, MP Van Antwerpen, GQ Shi, QX Chen, CJ Sindic and C Cocito
Microbiology & Genetics Unit, ICP, University of Louvain, Brussels, Belgium.

Tuberculous meningitis cases were analyzed by an immunoblotting test based on Mycobacterium bovis BCG antigen complex A60. Anti-A60 immunoglobulin G (IgG) in cerebrospinal fluid (CSF) allowed early diagnosis, and concentrations decreased after recovery. In primary meningitis forms, anti-A60 IgGs were intrathecally synthesized and specific oligoclonal IgGs were present in CSF. In meningeal complications of pulmonary tuberculosis, there were matching titers of anti-A60 IgG in blood and CSF (mirror pattern). Correlation between CSF- restricted patterns and CSF pleocytosis was shown.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1994 by the American Society for Microbiology. All rights reserved.