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Clinical and Diagnostic Laboratory Immunology, May 1994, 348-350, Vol 1, No. 3
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Levels of circulating fibronectin receptor in adult and pediatric patients with human immunodeficiency virus type 1 infection

D Torre, C Zeroli, A Pugliese, M Giola, G Ferrario, G Bonetta, M Issi, R Martegani, F Speranza and GP Fiori
Division of Infectious Diseases, Regional Hospital, Varese, Italy.

We found a significant increase in fibronectin receptor (FNR) levels in the sera of adult human immunodeficiency virus type 1 (HIV-1)-infected patients, especially in those with AIDS (1,026.9 +/- 583.9 ng/ml; P < 0.0001). In contrast, AIDS patients with neurologic disorders and HIV-1- seropositive patients showed normal levels of FNR in serum. In addition, HIV-1-infected children showed increased levels of FNR in serum (824.4 +/- 333.5 ng/ml; P = 0.03). We suggest that an increase of FNR levels in AIDS patients is related to enhanced expression of FNR on HIV-1-infected cells.




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Antimicrob. Agents Chemother. Clin. Microbiol. Rev. Infect. Immun.
J. Clin. Microbiol. J. Virol. ALL ASM JOURNALS

Copyright © 1994 by the American Society for Microbiology. All rights reserved.