Clinical and Diagnostic Laboratory Immunology, Jan 1994, 109-110, Vol 1, No. 1
Copyright © 1994 by the American Society for Microbiology. All rights reserved.

Transforming growth factor beta in Alzheimer's disease

CC Chao, S Hu, WH Frey 2nd, TA Ala, WW Tourtellotte and PK Peterson
Neuroimmunobiology and Host Defense Laboratory, Minneapolis Medical Research Foundation, MN 55404, USA.

Alzheimer's disease (AD) has been hypothesized to be an inflammatory condition. We hypothesized that anti-inflammatory cytokines, such as transforming growth factor beta (TGF-beta), counteract the inflammatory process. In the present study, we found that TGF-beta levels were elevated in both cerebrospinal fluid and serum samples obtained from AD patients < 6 h after death. Serum TGF-beta levels were also markedly elevated before death. These results suggest that elevated TGF-beta levels in AD may represent a protective host response to immunologically mediated neuronal injury.

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